Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

Conventional dendritic cells (cDCs) are critical to innate immunity and orchestrating adaptive T cell responses. cDCs originate from a common precursor and can be delineated into different subtypes. Cabeza-Cabrerizo et al. use multicolor fate mapping in mice to show that precursor cDCs enter tissue, differentiate into a single subtype, and proliferate as clones of sister cDCs under steady-state conditions.