Prostaglandin E2 (PGE2) switch on macrophage tissue repair properties to promote intestinal epithelial barrier regeneration in inflammatory bowel disease

Here, the team of Prof Gianluca Matteoi from the KU Leuven, Belgium and Prof. Seung Hyeok Seok from the Seoul National University College of Medicine, Korea describe a subset of prostaglandin receptor PTGER4-expressing intestinal macrophages with mucosal healing properties both in humans and mice.